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First, chronic administration of melatonin at .2 mg or above will create a
very interesting biological state in the brain. The natural release of
melatonin peaks at 0.2 mg at the same time as growth hormone, cortisol &
slow-wave sleep. It is not associated with REM sleep. It's more likely that
increased dream recall is occuring because of a slight REM rebound at the end
of the night, a compensatory reponse to an increase in NREM, especially
slow-wave sleep in the beginning of the night. Tryptophan is also associated
with deep NREM sleep, not REM. Tryptophan depletion results in shorter REM
latency and maybe increased REM time. Moreover, both melatonin & tryptophan
are related to serotonin production in the brain. Increasing serotonin, or
using drugs that inhibit serotonin re-uptake, such as Prozac, Zoloft & Paxil,
leaves more serotonin available in the brain and should, theoretically, reduce
REM sleep, not increase it. (That's exactly what these drugs do, but they are
also alerting & produce sleep fragmentation & microarousals, particularly at
the end of the night. Lightening or fragmenting sleep should improve the
likelhood of recalling a dream).

The natural physiological level of melatonin is a hundred-fold smaller than
what is available commercially. For every day use, 0.2 mg is much more
appropriate. To get over shift work, jet lag, or in some individuals with
biological rhythm disturbances, you may need a higher dose, but 2 mg every day
if you do not fall into one of the categories above is overkill and may be
associated with headache, and worse sleep disturbance than was evident prior
to taking the melatonin.

I urge extreme caution with high doses of melatonin because there is NO good
research on the long term effects.

The research data does not back up the grandiose claims of melatonin as a
wonder drug. It does shift the biological clock and can at small doses
improve sleep, particularly ease of sleep onset, and it does minimize
cardiac stress response in hamsters with chronic heart disease, but that is
the sum total of the good data.

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